.ALPHA.1,4-N-acetylglucosaminyltransferase and gastroenterology.
نویسندگان
چکیده
منابع مشابه
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
The dynamic modification of nuclear and cytoplasmic proteins with O-linked beta-N-acetylglucosamine (O-GlcNAc) by the O-linked N-acetylglucosaminyltransferase (OGT) is a regulatory post-translational modification that is responsive to various stimuli. Here, we demonstrate that OGT is a central factor for T- and B-lymphocytes activation. SiRNA-mediated knockdown of OGT in T cells leads to an imp...
متن کاملThe implication of N-acetylglucosaminyltransferase V expression in gastric cancer.
OBJECTIVE N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta(1-6) branching of N-acetylglucosamine on N-glycan of cell proteins, some of which are linked with metastasis. GnT-V expression was studied immunohistochemically in gastric cancer to compare clinicopathological parameters and evaluate the role of GnT-V in the prognosis of gastric cancer. METHODS Immunohisto...
متن کاملThe presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine.
Normal human urine was found to contain beta (1-3)N-acetylglucosaminyltransferase catalyzing the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose. Lacto-N-tetraose which carries the terminal Gal beta (1-3)GlcNAc structure was a poor acceptor. The product of the transferase reaction with N-acetyllactosamine as acceptor was identified by methylation analysis as G...
متن کاملN-glycans of Phaeodactylum tricornutum diatom and functional characterization of its N-acetylglucosaminyltransferase I enzyme.
N-glycosylation, a major co- and post-translational event in the synthesis of proteins in eukaryotes, is unknown in aquatic photosynthetic microalgae. In this paper, we describe the N-glycosylation pathway in the diatom Phaeodactylum tricornutum. Bio-informatic analysis of its genome revealed the presence of a complete set of sequences potentially encoding for proteins involved in the synthesis...
متن کاملN-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells.
The differentiation of naive CD4(+) T cells into either proinflammatory Th1 or proallergic Th2 cells strongly influences autoimmunity, allergy, and tumor immune surveillance. We previously demonstrated that beta1,6GlcNAc-branched complex-type (N-acetylglucosaminyltransferase V (Mgat5)) N-glycans on TCR are bound to galectins, an interaction that reduces TCR signaling by opposing agonist-induced...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SEIBUTSU BUTSURI KAGAKU
سال: 2002
ISSN: 0031-9082,1349-9785
DOI: 10.2198/sbk.46.55